Congratulations for being charitable. Contrary to what many think, charitable contributions are not a deductible business expense. They are deducted on your personal tax return, the 1040. Because of this, charitable contributions should ideally be made from a personal account rather than a business account.
If you do make a charitable contribution from a business account, it should be treated as a distribution or draw. I like to create a sub-account just for charitable contributions so that at year end, I have a number readily available.
A few points about what is a deductible charitable contribution. To be deductible, the organization you are contributing to should be a non-profit 501c3 organization. The organization should also send you a letter stating the amount of the donation and that they are a 501c3 organization. You need to keep these letters to document your contribution. Donations to political candidates and organizations are not deductible.